New Orleans Saints quarterback Drew Brees threw for 300 yards and four touchdown passes on 19 of 21 passing as the Saints took a 28-21 halftime lead vs. the New York Giants on Sunday at the Mercedes-Benz Superdome.

The Giants' Newman School connection - quarterback Eli Manning and receiver Odell Beckham Jr. - combined on two short touchdown passes to keep the Giants in the game. Manning also connected with running back Shane Vareen on a 2-yard TD pass on the final play of the quarter.

Colston (four catches for 85 yards, including a 53-yard TD) tied tight end Benjamin Watson with the most catches. Watson had four catches for 85 yards, with his long a 46-yarder that got the Saints away from their own goal line.

After going three and out on their first possession - which included a near-miss bomb to Cooks - the Saints scored the next four times they had the ball. First was a 34-yard Brees to Snead TD on a flea-flicker, then Cooks took a short Brees pass and raced into the end zone for a 26-yard score, Colston romped in from 53 yards as the Giants left him uncovered on the play and Snead caught a 2-yard TD pass from Brees with less than 2 minutes to play in the half.

Manning was 18 of 21 for 165 yards and the three touchdowns. He was sacked twice. Beckham had five catches for 32 yards and the two TDs.

Saints running back Khiry Robinson left the game on a cart late in the second quarter.