History: New Orleans Saints at San Francisco 49ers
The 49ers hold a 48-27-2 edge in the all-time series, but New Orleans took the win the last time these two teams met up in 2020. With the Saints and 49ers NFC West rivals from 1970-2001, San Francisco holds a 48-27-2 edge in the all-time regular season series, but the Saints have captured nine of the last 12. The San Francisco contest will close out New Orleans' 2022 slate against NFC West opponents.
Players and Coaches to Know
San Francisco 49ers
Head Coach: Kyle Shanahan
Quarterback: Jimmy Garoppolo
Key Position Players: TE George Kittle, RB Elijah Mitchell, WR Deebo Samuel, DL Nick Bosa
New Orleans Saints
Head Coach: Dennis Allen
Quarterback: Andy Dalton
Key Position Players: RB Alvin Kamara, WR Chris Olave, S Tyrann Mathieu
