Green Bay leads the series 16-7, following a 28-27 win at Lambeau Field on September 30, 2012. The Saints have posted a 5-5 record in contests at the Mercedes-Benz Superdome in the series. There have been two prime time contests between the Saints and Packers, a 51-29 win in the Mercedes-Benz Superdome on Nov. 24, 2008 and a 42-34 loss on Thursday, Sept. 8, 2011.
| Date | Score | Site | Attendance |
| 11/17/68 | L, 7-29 | Milwaukee County Std. | 49,644 |
| 11/28/71 | W, 29-21 | Milwaukee County Std. | 48,035 |
| 12/17/72 | L, 20-30 | Tulane Stadium | 65,881 |
| 12/2/73 | L, 10-30 | Milwaukee County Std. | 46,092 |
| 10/12/75 | W, 20-19 | Louisiana Superdome | 51,371 |
| 11/7/76 | L, 27-32 | Milwaukee County Std. | 52,936 |
| 9/18/77 | L, 20-24 | Louisiana Superdome | 56,250 |
| 9/10/78 | L, 17-28 | Milwaukee County Std. | 54,336 |
| 9/9/79 | L, 19-28 | Milwaukee County Std. | 53,184 |
| 12/13/81 | L, 7-35 | Louisiana Superdome | 45,518 |
| 11/4/84 | L, 13-23 | Louisiana Superdome | 57,426 |
| 11/17/85 | L, 14-38 | Milwaukee County Std. | 52,104 |
| 9/14/86 | W, 24-10 | Louisiana Superdome | 46,383 |
| 12/27/87 | W, 33-24 | Louisiana Superdome | 68,364 |
| 9/17/89 | L, 34-35 | Lambeau Field | 55,809 |
| 11/14/93 | L, 17-19 | Louisiana Superdome | 69,043 |
| 12/16/95 | L, 23-34 | Louisiana Superdome | 50,132 |
| 9/15/02 | W, 35-20 | Louisiana Superdome | 67,958 |
| 10/9/05 | L, 3-52 | Lambeau Field | 70,580 |
| 9/17/06 | W, 34-27 | Lambeau Field | 72,915 |
| 11/24/08 | W, 51-29 | Louisiana Superdome | 70,668 |
| 9/8/11 | L, 34-42 | Lambeau Field | 70,555 |
| 9/30/12 | L, 27-28 | Lambeau Field | 70,571 |
