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The New Orleans Saints host the San Francisco 49ers at the Mercedes-Benz Superdome on Sunday, December 8, 2019.

Teams combined for 981 yards of offense

Get postgame reactions from San Francisco 49ers head coach Kyle Shanahan, quarterback Jimmy Garoppolo, cornerback Richard Sherman, tight end George Kittle, and wide receiver Emmanuel Sanders

Get postgame reactions from Taysom Hill, Tre'Quan Smith, Marcus Williams, P.J. Williams, Cameron Jordan, Terron Armstead, and C.J. Gardner-Johnson

Get postgame reactions from New Orleans Saints quarterback Drew Brees

Get postgame reactions from New Orleans Saints head coach Sean Payton

Several New Orleans Saints players wore custom footwear as part of the NFL's My Cause, My Cleats campaign for Week 14 against the San Francisco 49ers.

New Orleans Saints quarterback Drew Brees recaps today's 48-46 loss to the San Francisco 49ers

New Orleans Saints head coach Sean Payton recaps today's 48-46 loss to the San Francisco 49ers

Check out the on-field entertainment during the Week 14 matchup between the Saints and 49ers at the Mercedes-Benz Superdome.

Brees has thrown 537 career TDs

Saints grip on top seed in NFC loosens

New Orleans Saints wide receiver Tre'Quan Smith spins from would-be tackle for go-ahead touchdown late.

He surpassed his 2018 total of 1,405 yards

New Orleans Saints wide receiver Michael Thomas gets open with great route for 21-yard touchdown.

New Orleans Saints quarterback Drew Brees' perfect pass hits wide receiver Michael Thomas in stride for huge 49-yard gain.

New Orleans Saints running back Latavius Murray bursts up the middle for 16 yards.

Tip drill! New Orleans Saints linebacker Craig Robertson grabs interception after pass deflects off San Francisco 49ers wide receiver Emmanual Sanders.

The New Orleans Saints host the San Francisco 49ers at the Mercedes-Benz Superdome on Sunday, December 8, 2019.

New Orleans Saints fans cheer on the team against the San Francisco 49ers at the Mercedes-Benz Superdome.

New Orleans Saints players prepare for week 14 before taking on the San Francisco 49ers at the Mercedes-Benz Superdome.

The Saintsations took to the field and performed for fans during Week 14 between the Saints and 49ers at the Mercedes-Benz Superdome.

Brees has thrown three TDs in first half

New Orleans Saints running back Latavius Murray turns short throw into HUGE tackle-breaking sideline tightrope.

San Francisco 49ers bite on New Orleans Saints' play action to open up tight end Josh Hill for a touchdown.

Taysom Hill leads the Saints pregame chant against the San Francisco 49ers.

New Orleans Saints wide receiver Deonte Harris breaks through defenders on 25-yard punt return.

New Orleans Saints linebacker Demario Davis drops San Francisco 49ers quarterback Jimmy Garoppolo for big loss on third-down sack.

New Orleans Saints quarterback Drew Brees  hypes up tight end Jared Cook on sidelines after touchdown.

Deonte Harris zooms through 49ers for 51-yard kick return.

Drew Brees serves up beautiful touch pass to tight end Jared Cook for early 38-yard touchdown.

Take a look at this field-level view of New Orleans Saints tight end Jared Cook's 38-yard touchdown reception vs. the San Francisco 49ers on Sunday, Dec. 8.

Field-view angle of the Saints pregame introduction vs. the San Francisco 49ers at the Mercedes-Benz Superdome.

Saints linebacker Demario Davis and quarterback Drew Brees lead the pregame huddle before the team prepares to face the San Francisco 49ers in the Mercedes-Benz Superdome on Sunday, Dec. 8.

Follow along with live tweets from the Saints, John DeShazier, Deuce McAllister, Zach Strief, and Caroline Gonzalez throughout the game

New Orleans Saints fans get ready for Week 14 against the San Francisco 49ers during our pregame party at Champions Square presented by Ticketmaster.

Kamara lets his play on the field do the talking for him

Linebackers Kiko Alonzo and A.J. Klein are out

How to watch, listen and live stream New Orleans Saints vs. San Francisco 49ers on December 8, 2019

Five Saints listed as OUT for Sunday vs. San Francisco

Get a Week 14 preview from San Francisco players and coaches