- With the win, New Orleans improves their record to 7-1 and extend their winning streak to six games. The Saints joint the New England Patriots as the only teams to have six-game winning streaks in each of the last three seasons.
- With the win, the Saints are now 4-0 in the Mercedes-Benz Superdome this season. The Saints start 4-0 at home for the first time since 2013, when they ended the season 8-0 in the Mercedes-Benz Superdome.
- The Saints' win improves their all-time record against the Cardinals to 15-15. Arizona is now the 11th team New Orleans has at least a .500 regular season record against.
- With the win, the Saints extend their home winning streak against the Cardinals to four games, extending to five straight wins including the 2009 NFC Divisional Playoff victory. This is the first four-game home win streak against the Cardinals in New Orleans franchise history.
- With the win, Head Coach Sean Payton improves his record against Arizona to 4-2 in the regular season and 5-2 including the playoffs. At home, Payton's record against the Cardinals improves to 3-0 all-time and 4-0 including postseason play.
- Cardinals Head Coach Kliff Kingsbury is now the 63rd coach Payton has defeated in his career and 46th coach Payton has a winning record against.
- Offensively, New Orleans racked up 510 yards of total offense, including 373 passing yards and 137 yards on the ground. 510 yards is the most Arizona has given up this season. The Saints surpassed 500 total yards of offense for the second time this season, and matched a season high for total yards gained (510 vs. Houston on September 9). 373 passing yards is New Orleans' highest passing total this season.
- New Orleans had nine different pass-catchers record at least one reception in the game, their highest total so far this season.
- Defensively, New Orleans held Arizona to 237 total yards, including 40 yards rushing and 197 yards passing. The Saints defense has now held their opponents to under 100 yards rushing for five consecutive games and has not given up 100 rushing yards to an individual player in 34 consecutive games. New Orleans held the Cardinals to less than 100 rushing yards for the first time since Week 2 of this season
- The Saints defense finished the afternoon with four sacks, moving their season total to 24. New Orleans has recorded at least four quarterback takedowns in three games this season.
- In his first game back from injury, QB Drew Brees finished 34-of-43 for 373 yards, three touchdowns, and one interception. Brees threw for three touchdowns for the first time since November 22, 2018, when he threw four against Atlanta.
- Brees became the first player in NFL history to eclipse 75,000 passing yards and now has 75,218 passing yards in his career. Brees has also now appeared in 267 games in his career, breaking a tie with Peyton Manning for sole possession of 26th place on the NFL's all-time games list.
- RB Latavius Murray carried the ball 21 times for 102 yards and one rushing touchdown and has now rushed for over 100 yards in back-to-back games for the first time in his career. Murray also added nine receptions for a career-high 55 receiving yards and his first career touchdown reception. Today marks Murray's eighth career multi-touchdown performance and marks the first time in his career that he has multiple touchdowns in back-to-back games.
- Murray surpassed 4,000 career rushing yards and 5,000 career yards from scrimmage in the game, as his career totals move to 4,057 rushing yards and 5,093 career yards from scrimmage.
- WR Michael Thomas scored his fourth touchdown of the season and 27th of his career, and finished with 11 receptions for 112 yards and a touchdown. Thomas surpassed 100 yards receiving for the 11th time in his career, which puts him in fifth place in the club record books.
- Thomas' 11 receptions move his career total to 394, surpassing tight end Jimmy Graham (386) for fourth place in team history.
- RB Dwayne Washington finished the afternoon with 38 rushing yards on three carries, including a new career-long carry of 31 yards coming on the Saints' final drive.
- QB Taysom Hill finished the game with three receptions for 63 yards and a touchdown, including the Saints' longest gain of the day – a 36-yard fourth quarter reception from Drew Brees. Hill has recorded touchdown receptions in back-to-back games for the first time in his career.
- Appearing in his 179th career game, WR Ted Ginn Jr. finished the afternoon with two receptions for 42 yards. With his next reception, Ginn will reach 400 for his career.
- TE Josh Hill recorded his fourth game with at least three receptions this season, finishing the afternoon with three catches for 39 yards. With two more receptions, Hill will reach 100 for his career.
- Appearing in his 136th career game, DE Cameron Jordan finished with two tackles, one sack, and one quarterback hit. With the sack, Cardinals QB Kyler Murray becomes the 32nd quarterback Jordan has dropped in his career.
- Jordan's 136 games played is tied with Tommy Myers for 24th on the club's all-time games played list. Jordan has also now amassed 79.5 sacks in his career. With his next 5 sack, Jordan will become only the third Saint all-time with 80 career quarterback takedowns, joining LB Ricky Jackson and DL Wayne Martin.
- LB Demario Davis led the Saints with eight tackles, his highest total since he recorded nine tackles in a Week 4 victory over Dallas.
- CB/S C.J. Gardner-Johnson finished the afternoon with five tackles and two pass defenses. Gardner-Johnson has now recorded two pass defenses in back-to-back weeks for the first time this season.
- DT David Onyemata recorded his second sack of the season, and now has recorded at least two takedowns in each of the past three seasons. Onyemata finished with two tackles, one quarterback hit, and the one sack.
- DT Shy Tuttle recorded a sack of Murray for his first career takedown. Tuttle finished with two tackles on the afternoon, a new season and career-high.
- DE Mario Edwards Jr. appeared in his 50th career game.
- K Wil Lutz scored the Saints' first points, converting a 26-yard field with 14:17 to play in the second quarter. Lutz finished the afternoon 1-for-2 on field goal attempts.
- P Thomas Morstead averaged 44 yards on two punts, including a 50-yard punt with 9:14 to play in the game.
- The Saints extended their streak to 280 regular season games without having been shutout. The streak dates back to a 26-20 victory at Tampa Bay on September 6, 2002 and is the longest running streak in the NFL and fourth longest streak all-time
