First Round picks in the 2015 NFL Draft
| Pick | Team | Player | Position | School |
| 1 | Tampa Bay Buccaneers | Jameis Winston | QB | Florida St. |
| 2 | Tennessee Titans | Marcus Mariota | QB | Oregon |
| 3 | Jacksonville Jaguars | Dante Fowler Jr. | LB | Florida |
| 4 | Oakland Raiders | Amari Cooper | WR | Alabama |
| 5 | Washington Redskins | Brandon Scherff | OG | Iowa |
| 6 | New York Jets | Leonard Williams | DE | USC |
| 7 | Chicago Bears | Kevin White | WR | West Virginia |
| 8 | Atlanta Falcons | Vic Beasley | LB | Clemson |
| 9 | New York Giants | Ereck Flowers | OG | Miami |
| 10 | St. Louis Rams | Todd Gurley | RB | Georgia |
| 11 | Minnesota Vikings | Trae Waynes | CB | Michigan St. |
| 12 | Cleveland Browns | Danny Shelton | NT | Washington |
| 13 | New Orleans Saints | Andrus Peat | OT | Stanford |
| 14 | Miami Dolphins | DeVante Parker | WR | Louisville |
| 15 | San Diego Chargers | Melvin Gordon | RB | Wisconsin |
| 16 | Houston Texans | Kevin Johnson | CB | Wake Forest |
| 17 | San Francisco 49ers (via Chargers) | Arik Armstead | DT | Oregon |
| 18 | Kansas City Chiefs | Marcus Peters | CB | Washington |
| 19 | Cleveland Browns (via Bills) | Cameron Erving | C | Florida St. |
| 20 | Philadelphia Eagles | Nelson Agholor | WR | USC |
| 21 | Cincinnati Bengals | Cedric Ogbuehi | OT | Texas A&M |
| 22 | Pittsburgh Steelers | Bud Dupree | LB | Kentucky |
| 23 | Denver Broncos (via Lions) | Shane Ray | DE | Missouri |
| 24 | Arizona Cardinals | D.J. Humphries | OT | Florida |
| 25 | Carolina Panthers | Shaq Thompson | LB | Washington |
| 26 | Baltimore Ravens | Breshad Perriman | WR | Central Florida |
| 27 | Dallas Cowboys | Byron Jones | CB | Connecticut |
| 28 | Detroit Lions | Laken Tomlinson | OG | Duke |
| 29 | Indianapolis Colts | Phillip Dorsett | WR | Miami |
| 30 | Green Bay Packers | Damarious Randall | FS | Arizona State |
| 31 | New Orleans Saints | Stephone Anthony | LB | Clemson |
| 32 | New England Patriots | Malcom Brown | DT | Texas |
