The Saints are 7-7 all-time against Pittsburgh, which will host New Orleans for only the second time at Heinz Field. The Saints have a 2-3 record against the Steelers in games played in Pittsburgh. The Steelers are one of the Saints' most infrequent opponents. The two teams have only played four times since 1993, the least meetings the Saints have had with an NFL foe over that span – excluding the Texans, who entered the NFL in 2002.
When scoring 16 points or more, the Saints are 7-1 in the series.
On Nov. 19, 1984, the Saints won the first "Monday Night Football" game in club history with a 27-24 victory at the Superdome. New Orleans had entered the game 0-6 on "MNF"...New Orleans and Pittsburgh were division foes in 1968 when both teams were part of the Century Division. They played twice that season, with the Saints winning both games.
A look back at the results between the Saints and Steelers in the previous 14 meetings:
| Date | Score | Site | Attendance |
| 10/29/67 | L, 10-14 | Tulane Stadium | 68,911 |
| 10/20/68 | W, 16-12 | Pittsburgh Stadium | 32,303 |
| 12/15/68 | W, 24-14 | Tulane Stadium | 66,131 |
| 12/21/69 | W, 27-24 | Tulane Stadium | 72,256 |
| 11/25/74 | L, 7-28 | Tulane Stadium | 71,907 |
| 11/5/78 | L, 14-20 | Three Rivers Stadium | 48,526 |
| 10/4/81 | L, 6-20 | Superdome | 64,578 |
| 11/19/84 | W, 27-24 | Superdome | 66,005 |
| 11/29/87 | W, 20-16 | Three Rivers Stadium | 47,896 |
| 12/16/90 | L, 6-9 | Superdome | 68,582 |
| 10/17/93 | L, 14-37 | Three Rivers Stadium | 56,056 |
| 10/6/02 | W, 32-29 | Superdome | 67,734 |
| 11/12/06 | L, 31-38 | Heinz Field | 61,911 |
| 10/31/10 | W, 20-10 | Superdome | 70,011 |
