New Orleans is 4-12 all-time against the Browns. The two clubs were both members of the NFL's Century Division in 1968, New Orleans' second season as a franchise.
In the only game they've played at FirstEnergy Stadium, the Saints opened up the Sean Payton and Drew Brees era by defeating the Browns in the 2006 opener, 19-14.
| Date | Score | Site | Attendance |
| 10/1/67 | L, 7-42 | Tulane Stadium | 77,045 |
| 9/15/68 | L, 10-24 | Tulane Stadium | 74,215 |
| 11/10/68 | L, 17-35 | Municipal Stadium | 71,025 |
| 10/12/69 | L, 17-27 | Tulane Stadium | 71,274 |
| 12/12/71 | L, 17-21 | Tulane Stadium | 72,794 |
| 11/30/75 | L, 16-17 | Municipal Stadium | 44,753 |
| 10/8/78 | L, 16-24 | Louisiana Superdome | 50,158 |
| 10/18/81 | L, 17-20 | Municipal Stadium | 76,059 |
| 10/28/84 | W, 16-14 | Municipal Stadium | 52,489 |
| 9/13/87 | W, 28-21 | Louisiana Superdome | 59,900 |
| 10/14/90 | W, 25-20 | Louisiana Superdome | 68,608 |
| 12/5/93 | L, 13-17 | Municipal Stadium | 60,388 |
| 10/31/99 | L, 16-21 | Louisiana Superdome | 48,817 |
| 11/24/02 | L, 15-24 | Louisiana Superdome | 68,295 |
| 9/10/06 | W, 19-14 | Cleveland Browns Stadium | 72,915 |
| 10/24/10 | L, 17-30 | Louisiana Superdome | 70,077 |
