The Saints and the Eagles first met on Nov. 5, 1967, with New Orleans posting a 31-24 victory at Tulane Stadium. It was the first win in franchise history, coming in week eight of the Saints' inaugural season. The Saints are 3-8 at Philadelphia (0-3 at Franklin Field, 2-4 Veterans Stadium, 1-1 at Lincoln Financial Field).
The Saints have a 11-15 regular season record and a 1-1 mark in the postseason vs. the Eagles. New Orleans' 48-22 win on Sept. 20, 2009 at Lincoln Financial Field was the Saints' first win at Philadelphia since 1991. In the postseason, the Saints defeated the Eagles 27-24 at home in the Divisional Playoffs, Jan. 13, 2007, advancing to the NFC Championship for the first time in franchise history.
Ten of the regular season games in the all-time series have been decided by a touchdown or less. A look back on the all-time results:
| Date | Score | Site | Attendance |
| 11/5/67 | W, 31-24 | Tulane Stadium | 59,596 |
| 11/19/67 | L, 21-48 | Franklin Field | 60,751 |
| 12/8/68 | L, 7-29 | Franklin Field | 57,128 |
| 10/26/69 | L, 10-13 | Franklin Field | 60,568 |
| 11/30/69 | W, 26-17 | Tulane Stadium | 72,805 |
| 10/29/72 | W, 21-3 | Tulane Stadium | 65,664 |
| 10/27/74 | W, 14-10 | Tulane Stadium | 64,257 |
| 11/6/77 | L, 7-28 | Veterans Stadium | 53,482 |
| 9/17/78 | L, 17-24 | Superdome | 49,242 |
| 9/16/79 | L, 14-26 | Superdome | 54,212 |
| 11/9/80 | L, 21-34 | Superdome | 44,340 |
| 10/11/81 | L, 14-31 | Superdome | 52,728 |
| 12/11/83 | W, 20-17 ot | Veterans Stadium | 45,182 |
| 10/6/85 | W, 23-21 | Superdome | 56,364 |
| 9/20/87 | L, 17-27 | Veterans Stadium | 57,485 |
| 12/18/89 | W, 30-20 | Superdome | 59,218 |
| 10/13/91 | W, 13-6 | Veterans Stadium | 64,224 |
| 9/6/92 | L, 13-15 | Veterans Stadium | 63,513 |
| 1/3/93 | L, 20-36 | Superdome | 68,893 |
| 12/26/93 | L, 26-37 | Veterans Stadium | 50,085 |
| 10/1/95 | L, 10-15 | Superdome | 43,938 |
| 9/24/00 | L, 7-21 | Superdome | 64,900 |
| 11/23/03 | L, 20-33 | Lincoln Financial Field | 67,802 |
| 10/15/06 | W, 27-24 | Superdome | 68,269 |
| 1/13/07 | W, 27-24 | Superdome | 70,001 |
